CD22 anticorps

N° du produit ABIN370867

Cet anticorps Rat Monoclonal détecte spécifiquement CD22 dans FACS et Func. Il présente une réactivité envers Souris.

Aperçu rapide pour CD22 anticorps (ABIN370867)

Antigène: CD22 (CD22 Molecule (CD22))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp CD22 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: 2D6

Détail du produit anti-CD22 anticorps

Specificité: This antibody is specific to CD22 (Mr 150 kDa), a B Lymphocyte Adhesion Molecule.

Attributs du produit: Synonyms: SIGLEC2, Siglec-2, B-cell receptor CD22, Leu-14, BL-CAM, Sialic acid-binding Ig-like lectin 2,B-lymphocyte cell adhesion molecule

niveau d'endotoxine: Low Endotoxin

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry. (Ref.2)Functional Assay: Blocking of B cell homotypic adhesion. (Ref.2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS without preservatives.

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CD22

Antigène: CD22 (CD22 Molecule (CD22))

Autre désignation: CD22

Sujet: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. (Ref.1,2) CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. (Ref.2-4) Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation. (Ref.6-9)Synonyms: B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, Leu-14, SIGLEC2, Sialic acid-binding Ig-like lectin 2, Siglec-2

ID gène: 12483

UniProt: P35329